The Biophysical Instrumentation Facility (BIF) houses instrumentation for aiding in the elucidation of macromolecular structure. The facility was established by Dr. Barbara Imperiali and is located in the Koch Biology Building (68-470), not the new Koch Institute. It is largely used by researchers in Chemistry, Biology and BioEngineering but is available to anyone on campus and beyond. The BIF is a BL1 facility. It is staffed 40 hours a week by Debby Pheasant who is available to train new users and provide advice to anyone considering potential applications of the equipment in the facility. For inquiries, contact Debby Pheasant at

Instruments Applications Location
Beckman XL-I Analytical Ultracentrifuge calculating the molecular mass, stoichiometry, conformation and shape of proteins in solution 68-470
Aviv Model 202 Circular Dichroism Spectrometer information on secondary structure: alpha-helix, beta-sheet or random coil 68-470
MicroCal Differential Scanning Calorimeter information about subunit composition, folding and stability 68-470
DynaPro NanoStar Light Scatterer molecular weights of the different species in a sample and their size distribution 68-470
Beckman PA 800 Capillary Electrophoresis high-resolution analytical separation of molecules based on size and charge 68-470
ForteBio Octet RED96 Assays for protein quantitation and biomolecular kinetics 68-470
MicroCal Isothermal Titration Calorimeter binding constants measured with both binding partners in solution 68-470