Jeffrey Karp - Inspiration from a porcupine's quills
Understanding the mechanisms behind quill penetration and extraction
could help engineers design better medical devices.
Anne Trafton, MIT News Office
December 10, 2012
Anyone unfortunate enough to encounter a porcupine’s quills knows that once they go in,
they are extremely difficult to remove. Researchers at MIT and Brigham and Women’s
Hospital now hope to exploit the porcupine quill’s unique properties to develop new types of
adhesives, needles and other medical devices.
In a new study, the researchers characterized, for the first time, the forces needed for quills
to enter and exit the skin. They also created artificial devices with the same mechanical
features as the quills, raising the possibility of designing less-painful needles, or adhesives
that can bind internal tissues more securely.
There is a great need for such adhesives, especially for patients who have undergone
gastric-bypass surgery or other types of gastric or intestinal surgery, according to the
researchers. These surgical incisions are now sealed with sutures or staples, which can
leak and cause complications.
“With further research, biomaterials modeled based on porcupine quills could provide a new class of adhesive materials,” says Robert Langer, the David
H. Koch Institute Professor at MIT and a senior author of the study, which appears this week in the Proceedings of the National Academy of Sciences.
Jeffrey Karp, an associate professor of medicine at Harvard Medical School and co-director of the Center for Regenerative Therapeutics at Brigham
and Women’s Hospital, is also a senior author of the paper. Lead author is Woo Kyung Cho, a postdoc in the Harvard-MIT Division of Health Sciences
and Technology (HST).
Borrowing from nature
Aside from stitches and sutures, doctors sometimes use medical-grade superglue to bind tissue together, Karp says. However, those glues can be toxic,
or provoke an inflammatory response.
To create adhesives that would work in the body without producing adverse reactions, the research team turned to nature for inspiration. “We believe
that evolution is the best problem-solver,” Karp says.
In this case, they became interested in the North American porcupine, which has about 30,000 barbed quills to defend against predators. Each quill is several centimeters long; the four millimeters at the very tip are covered in microscopic
To their surprise, the researchers found that despite the difficulty of removing the quills,
they require very little force to penetrate tissue. Compared to quills with no barbs, the
barbed quills require about 50 percent less force to penetrate muscle tissue.
The team then set out to determine how the quills achieve this unique combination of easy
penetration and difficult removal. “By understanding the mechanism, we can design an
artificial system in the right way,” Cho says.
They found that the tiny barbs at the end of the quill are the key to both ease of penetration
and resistance to removal. While the quill is entering tissue, the barbs act to localize the
penetration forces, allowing them to tear through tissue fibers much more easily — just as
a serrated knife cuts through tomato skin far more cleanly than a straight-edged knife.
When it comes to the force required for pullout, the barbs act like anchors that keep the
quill from coming out. The force required to pull out barbed quills is four times that required
to remove barbless quills.
Toward new adhesives
The discovery that barbed quills require so little force to penetrate skin is both unexpected
and fascinating, says Michael Longaker, a professor of surgery at Stanford University
School of Medicine. Devices that mimic the quills could be very helpful in securing tissue
during and after surgery, he says. “That combination of ‘easy to get in’ and ‘difficult to pull
out’ would be really appealing,” says Longaker, who was not part of the research team.
To explore the possibility of making stronger adhesives, the researchers created a patch with an array of barbed quills on one side. They found that the
energy required to remove this patch was 30 times greater than that needed for a control patch, which had quills but no barbs.
The system could also be tweaked so that it penetrates tissue easily but is not as difficult to remove as a porcupine quill, enabling design of less-painful
needles for injections. “If you can still create the stress concentrations but without having a barb that catches tissue on removal, potentially you could
create something with just easy insertion, without the adhesion,” says James Ankrum, a graduate student in HST and an author of the paper.
Langer and Karp introduced the concept of gecko-inspired medical bandages in 2008; however, “these require a reactive glue to adhere to wet tissues,
while porcupine-quill-inspired adhesives attach to tissues beautifully without requiring the use of reactive chemistry,” Karp says. “They are extremely
versatile and potentially universal in their application.”
Other authors of the paper are Dagang Guo, a visiting scientist at Harvard Medical School; Shawn Chester, an MIT graduate student; Seung Yun Yang,
a postdoc at Brigham and Women’s Hospital; Anurag Kashyap, Georgina Campbell, Ram Rijal, research assistants at Brigham and Women’s Hospital;
Robert Wood, an associate professor of engineering at Harvard; and Rohit Karnik, an MIT associate professor of mechanical engineering.
The researchers are now working on making quill-inspired adhesives from biodegradable materials, which could be broken down inside the body after
they are no longer needed.
The research was funded by the National Institutes of Health, the American Heart Association, the National Science Foundation and the National
Research Foundation of Korea.