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Sangeeta N. Bhatia, Ph.D.

Department of Health Sciences and Technology
Associate Professor of Health Sciences and Technology
Associate Professor of Electrical Engineering and Computer Science

617-324-0221 (phone)

Biosketch

PhD in Medical Engineering and Medical Physics, MIT, 1997
MD, Harvard Medical School, HST, 1999
MS, Mechanical Engineering, MIT
ScB with honors, Brown University, 1990

Research Summary

Dr. Bhatia's research in the Laboratory for Multiscale Regenerative Technologies is focused on the applications of micro- and nanotechnology to tissue repair and regeneration.

Specifically, she studies the interactions between hepatocytes (liver cells) and their microenvironment and develops microfabrication tools to improve cellular therapies for liver disease (Hepatic Tissue Engineering). The goal is to maximize hepatocyte function, facilitate design of effective cellular therapies for liver disease, and improve fundamental understanding of liver physiology and pathophysiology. She is also interested in using arrays of living cells as high-throughput platforms to study fundamental aspects of stem cell biology (Cell-Based BioMEMS) using a diverse repertoire of tools including chemical, topological, fluidic, electrical, and optical manipulation of living cells on chip platforms. Finally, LMRT is involved in a multidisciplinary effort to develop nanomaterials as tools for biological studies and as multifunctional agents for cancer therapies. Interests center around nanoparticles and nanoporous materials that can be designed to perform complex tasks such as: home to a tumor, sense changes in cells and tissues, enhance imaging, and trigger the release of a therapeutic payload. Having had several stints in the biotechnology industry, Dr. Bhatia holds a number of patents for both clinical and biotechnological applications of engineering principles. She is the author of Microfabrication in Tissue Engineering and Bioartificial Organs and co-author of the undergraduate textbook Tissue Engineering.

Selected Publications

  • Liu Tsang, V, Chen, AA, Cho, LM, Jadin, KD, Sah, RL, DeLong, S, West, JL, and Bhatia, SN (2007) Fabrication of 3D Hepatic Tissues by Additive Photopatterning of Cellular Hydrogels. FASEB Journal, 21: 790-801.
  • Harris TJ, von Maltzahn, G, Derfus AM, Rouslahti E, Bhatia SN (2006): Proteolytic Actuation of Nanoparticle Self-Assembly. Agnewandte Chemie International Edition, 41(19): 3161-3165.
  • Albrecht, DR, Underhill, GH, Wassermann, TB, Sah, RL, Bhatia, SN (2006): Probing the Role of Multicellular Organization in 3D Microenvironments. Nature Methods, 3: 369-375.
  • Khetani, S.R., and Bhatia, S.N. (2006) Engineering Tissues for in vitro Applications. Current Opinion in Biotechnology, 17: 524-531.
  • Flaim, C., Chien, S, Bhatia, S.N. (2005): An Extracellular Matrix Microarray for Probing Cellular Differentiation. Nature Methods 2(2): 119-125.
  • Chen, AA, Derfus, AM, Khetani, SR, Bhatia, SN (2005): Quantum Dots to Monitor RNAi Delivery and Improve Gene Silencing. Nucleic Acids Research, 33 (22): e190.

Last Updated: April 16, 2008