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Ernest Fraenkel, Ph.D.

Department of Biological Engineering
Associate Professor

Room 68-323A
617-258-8702 (phone)
617-395-2652 (fax)


A.B. Chemistry & Physics, Harvard College, 1990
Ph.D. Biology, MIT, 1998
Whitehead Fellow, Whitehead Institute for Biomedical Research, 2001-2005
Research Affiliate, MIT Computer Science and AI Laboratory, 2002-present
Assistant Prof., Dept. of Biological Engineering, MIT, 2006-2009
Associate Prof., Dept. of Biological Engineering, MIT, 2010-present
Associate Member, Broad Institute, 2009-present

Research Summary

Systems Biology of Disease

We are developing computational and experimental approaches to search for new therapeutic strategies for diseases. New experimental methods make it possible to measure cellular changes across the genome and proteome. These technologies include genome-wide measurements of transcription, of protein-DNA interactions (ChIP-Seq), of genetic interactions, and of protein modifications. Each data source provides a very narrow view of the cellular changes. However, by computationally integrating these data we can reconstruct signaling pathways and identify previously unrecognized regulatory mechanisms that contribute to the etiology of disease and may provide new approaches for treatment.

Current projects focus on the study of cancer, neurodegenerative diseases and diabetes.


Click here for a complete list of publications.

Last Updated: September 22, 2010