Chris Kaiser, Ph.D.

Department of Biological Engineering Division
Assistant Professor

Room 48-317
617-253-2726 (phone)
617-252-1816 (fax)


B.S., 1995, University of Illinois, Urbana
M.S., 1997, University of California, Riverside
Ph.D., 2001, University of Washington, Seattle
Postdoc, 2005, University of California, Berkeley/Lawrence Berkeley National Laboratory

Research Summary

Research in my group includes both computational/theoretical and experimental approaches to understanding the evolution of microorganisms, emphasizing a 'systems-level' perspective. Some areas of special interest include:

  • Tools for detecting natural selection in microbes
  • The evolutionary origin of gene families
  • Mining metagenomic sequence data
  • Experimental evolution of microbes
  • Modeling bacterial ecology
  • Gene regulatory networks in bacteria
  • Protein structure and design

Teaching Interests

I have enjoyed teaching a variety of classes at MIT, spanning my own diverse interests in microbiology, computer algorithms, and thermodynamics of biomolecules. I am currently looking forward to teaching a new class on microbial evolution and genetics.

Selected Publications

  • Shapiro B.J. and Alm E.J. Comparing Patterns of Natural Selection Across Species Using Selective Signatures. PloS Genetics. In press.
  • Price, M.N., Arkin, A.P. and Alm, E.J.(*) (2006) The life-cycle of operons. PLoS Genetics, 2, e96
  • Alm, E., Huang, K. and Arkin, A. (2006) The evolution of two-component systems in bacteria reveals different strategies for niche adaptation. PLoS Comput Biol, 2, e143.
  • Alm, E. and Arkin, A.P. (2003) Biological networks. Curr Opin Struct Biol, 13, 193-202.
  • Alm, E. and Baker, D. (1999) Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures. Proc Natl Acad Sci U S A, 96, 11305-11310.

    (* - corresponding author)

    View entire publications list

Last Updated: April 12, 2009