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Jeffrey M. Karp, Ph.D.

Department of Health Sciences and Technology
Instructor in Medicine and Health Sciences and Technology, Harvard Medical School
Brigham & Women's Hospital
Director, Laboratory for Advanced Biomaterials and Stem-Cell-Based Therapeutics,
Brigham & Women's Hospital
Co-director of the Center For Regenerative Therapeutics, Brigham & Women's Hospital

617-817-9174 (phone)


PhD in Chemical and Biomedical Engineering, University of Toronto, 2004
BEng in Chemical Engineering, McGill University, 1999

Research Summary

Current tissue engineering strategies are taking far too long to reach the clinic. We have a moral obligation not only to solve problems that can benefit patients of the future but also to develop strategies that can rapidly be translated to the clinic to help patients today. Our lab aims to create advanced biomaterials and devices for therapeutics through a highly multidisciplinary approach. Through working at the interface of material science, biology engineering, and medicine, our highly interactive and collaborative group engages outstanding scientists and clinicians at MIT, Harvard, Brigham and Women's Hospital and surrounding hospitals and institutions. A major focus of our group is the study and development of polymers and stem cells for addressing the biggest limitations in engineering replacement tissues and organs. We are dedicated to the development of next generation bioengineers to work at the forefront of regenerative medicine. Specific interests include: development of polymeric devices and stem-cell-based therapeutics to address key limitations in engineering replacement tissues and organs as well as biomimetic devices for cancer therapy and regenerative medicine.

Selected Publications

  • Sarkar D, Vemula PK, Zhao W, Gupta A, Karnik R, Karp JM. Engineered mesenchymal stem cells with self-assembled vesicles for systemic cell targeting. Biomaterials. 2010 Jul; 31(19):5266-74.
  • Ankrum J, Karp JM. Mesenchymal stem cell therapy: Two steps forward, one step back. Trends Mol Med. 2010 May; 16(5):203-9.
  • Amin SB, Karp JM, Benzley LP. Unconjugated hyperbilirubinemia and early childhood caries in a diverse group of neonates. Am J Perinatol. 2010 May; 27(5):393-7.
  • Zhao W, Karp JM. Controlling cell fate in vivo. Chembiochem. 2009 Sep 21; 10(14):2308-10.
  • Karp JM. Dental surgery under general anesthesia for preschool patients with orofacial clefts. Pediatr Dent. 2009 Sep-Oct; 31(5):426-31.
  • Karp JM, Milner LA. Oral eruption cysts in a child with hepatoblastoma. J Pediatr Hematol Oncol. 2009 Jul; 31(7):509-11.
  • Zhao W, Karp JM. Tumour targeting: Nanoantennas heat up. Nat Mater. 2009 Jun; 8(6):453-4.
  • Karp JM, Leng Teo GS. Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell. 2009 Mar 6; 4(3):206-16.
  • Berkowitz RJ, Koo H, McDermott MP, Whelehan MT, Ragusa P, Kopycka-Kedzierawski DT, Karp JM, Billings R. Adjunctive chemotherapeutic suppression of mutans streptococci in the setting of severe early childhood caries: an exploratory study. J Public Health Dent. 2009; 69(3):163-7.
  • El Gammal R, Fernandez C, Abdessalam S, Chase L, Scherr R, Karp JM. Index of suspicion. Pediatr Rev. 2008 Dec; 29(12):437-44.

Last Updated: January 19, 2011