Links for Additional Information

Matthew J. Lang, Ph.D.

Department of Biological Engineering Division
Assistant Professor of Mechanical Engineering, and Biological Engineering

Room NE47-221
617-452-2631 (phone)

Biosketch

B.S. University of Rochester
Ph.D. University of Chicago
Post-Doctoral Fellow, U.C. Berkeley, (Prof. Graham R. Fleming)
Department of Chemistry and the Physical Biosciences Division LBNL
Post-Doctoral Fellow, Princeton University, (Prof. Steven M. Block)
Department of Molecular Biology and the Princeton Materials Institute
Jane Coffin Childs Postdoctoral Fellow, Stanford University, (Prof. Block)
Departments of Biological Sciences and Applied Physics

Research Summary

My general research interests lie in elucidating the inner-workings of proteins, enzymes and biological motors, using instrumentation that combines optical tweezers, single molecule fluorescence and pulsed spectroscopy. This research will be directed towards developing a molecular level description of the motions associated with structural, mechanical, dynamic and energetic changes of these biological systems. Through these emerging technologies, significant advances in our ability to measure receptor/ligand interactions, the inner-workings of biological motors and interactions between multi-unit protein complexes will be achieved, thus providing a deeper understanding of these biological systems.

Selected Publications

  • Active particle control through silicon using conventional optical trapping techniques. Appleyard, D.C., and Lang, M.J.(2007) Lab on a Chip 7: 1837-1840. Link
  • Geometric Confinement Influences Cellular Mechanical Properties II - Intracellular Variances in Polarized Cells. Su, J., Brau, R.R., Jiang, X., Whitesides, G.M., Lang, M.J., So, P.T.C. (2007) Molecular & Cellular Biomechanics. 4 (2): 105-118. PDF
  • Passive and active microrheology with optical tweezers. Brau, R.R., Ferrer, J.M., Lee, H.S., Castro, C.E., Tam, B.K., Tarsa, P.B., Matsudaira, P., Boyce, M.C., Kamm, R.D., Lang, M.J. (2007) Journal of Optics A: Pure and Applied Optics 9 (2007) S103-S112. Link
  • Single M13 bacteriophage tethering and stretching (Cover Article). Khalil, A.S., Ferrer, J.M., Brau, R.R., Kottmann, S.T., Noren, C.J., Lang, M.J., Belcher, A.M. (2007) Proceedings of the National Academy of Sciences. 104: 4892-4897. PDF
  • Detecting Force-Induced Molecular Transitions with Florescence Resonant Energy Transfer. Tarsa, P.B., Brau, R.R., Barch, M., Ferrer, J.M., Freyzon, Y., Matsudaira, P., Lang, M.J. (2007) Angewandte Chemie, International Edition 46(12): 1999-2001. Link
  • Effect of plasmodial RESA protein on deformability of human red blood cells harboring Plasmodium falciparum. J.P. Mills, M. Diez-Silva, D.J. Quinn, M. Dao, M.J. Lang, K.S.W. Tan, C.T. Lim, G. Milon, P.H. David, O. Mercereau-Puijalon, S. Bonnefoy, S. Suresh. (2007) Proceedings of the National Academy of Sciences 104, 22 (2007) 9213-9217. PDF
  • Force of an Actin Spring. Shin, J.H., Tam, B.K., Brau, R.R., Lang, M.J., Mahadevan, L., Matsudaira, P. (2007) Biophysical Journal. 92: 3729-3733. PDF
  • Optical Trapping for Undergraduates. Appleyard, D.C., Vandermeulen, K., Lee, H., Lang, M.J. (2007) American Journal of Physics. 75(1): 5-14. PDF
  • Interlaced optical force-fluorescence measurements for single molecule biophysics. Brau, R.R., Tarsa, P.B., Ferrer, J.M., Lee, P., Lang, M.J. (2006) Biophysical Journal 91(3): 1069-1077. PDF
  • Simultaneous, coincident optical trapping and single-molecule fluorescence. Lang, M.J., Fordyce, P.M., Engh, A.M., Neuman, K.C., Block, S.M. (2004) Nature Methods 1(2): 133-139. PDF
  • Combined optical trapping and single-molecule fluorescence. Lang, M.J., Fordyce, P.M., and Block, S.M. (2003) Journal of Biology 2(1): 6. PDF
  • Probing the kinesin reaction cycle with a 2D optical force clamp. Block, S.M., Asbury, C.L., Shaevitz, J.W., and Lang, M.J. (2003) Proceedings of the National Academy of Sciences 100(5): 2351. PDF
  • LBOT-1: Laser-based optical tweezers. Lang, M.J., and Block, S.M. (2003) American Journal of Physics 71(3): 201. PDF
  • An Automated Two-Dimensional Optical Force Clamp for Single Molecule Studies. Lang, M.J., Asbury, C.L., Shaevitz, J.W., and Block, S.M. (2002). Biophysical Journal 83(1): 491. PDF
  • A 2D Force Clamp for Kinesin with Fluorescence Capability. M.J. Lang, C.L. Asbury, J.W. Shaevitz and S.M. Block. (2001) Biophysical Journal 80(1): 571a. PDF
  • The Effect of 2D Forces on Kinesin Motility. M.J. Lang, J.W. Shaevitz, C.L. Asbury, and S.M. Block. (2002) Biophysical Journal 82(1): 62a. PDF
  • Aqueous Solvation Dynamics Studied by Photon Echo Spectroscopy. M.J. Lang, X. J. Jordanides, X. Song and G. R. Fleming. (1999) Journal of Chemical Physics 110(12): 5884. PDF
  • Solvation Dynamics in Protein Environments Studied by Photon Echo Spectroscopy. X. J. Jordanides, M. J. Lang, X. Song and G. R. Fleming. (1999) Journal of Physical Chemistry B 103(37): 7995. PDF
  • Photoinduced electron transfers through sigma bonds in solution. N.C.C. Yang, S.L. Zhang, M.J. Lang, S. Goodman, C. Durnell, G.R. Fleming, H.L. Carrell, R.M. Garavito. (1999) in Electron Transfer - From Isolated Molecules to Biomolecules, Part 1: 645.
  • The intermolecular interaction mechanisms in liquid CS2 at 299 K and 164 K probed with two-dimensional Raman spectroscopy. A. Tokmakoff, M.J. Lang, X.S. Jordanides and G.R. Fleming. (1998) Chemical Physics 233(2-3): 231. PDF
  • Two-Dimensional Raman Spectroscopy of Vibrational Interactions in Liquids. A. Tokmakoff, M.J. Lang, D.S. Larsen, G.R. Fleming, V. Chernyak and S. Mukamel (1997) Physical Review Letters 79(14): 2702. PDF
  • Intrinsic Optical Heterodyne Detection of a Two-Dimensional Fifth Order Raman Response. A. Tokmakoff, M. J. Lang, D.S. Larsen and G.R. Fleming. (1997) Chemical Physics Letters 272(1-2): 48. PDF
  • Direct Measurement of Intrinsic Proton Transfer Rates in Diffusion Controlled Reactions. E. Pines, B-Z. Magnes, M.J. Lang and G.R. Fleming. (1997) Chemical Physics Letters 281(4-6): 413. PDF
  • Pump-Probe Polarization Anisotropy Study of Femtosecond Energy Transfer within the Photosynthetic Reaction Center of Rhodobacter sphaeroides R26. D.M. Jonas, M.J. Lang, Y. Nagasawa, T. Joo and G.R. Fleming. (1996) Journal of Physical Chemistry 100(30): 12660. PDF
  • Third-Order Nonlinear Time Domain Probes of Solvation Dynamics. T. Joo, Y. Jia, J-Y. Yu, M.J. Lang and G.R. Fleming. (1996) Journal of Chemical Physics 104(16): 6089. PDF
  • Energy Transfer in the Photosynthetic Reaction Center. D.M. Jonas, M.J. Lang, Y. Nagasawa, and G.R. Fleming. (1996) in Ultrafast Phenomena X,62, Springer, p. 336.
  • Donor-Acceptor Interaction and Photochemistry of Polymethylene-linked Bichromophores in Solution. S-L. Zhang, M.J. Lang, S. Goodman, C. Durnell, V. Fidler, G.R. Fleming, and N.-C. Yang. (1996) Journal of the American Chemical Society 118(38): 9042. PDF
  • Energy Transfer and Trapping in Photosystem I Reaction Centers from Cyanobacteria. L. DiMagno, C-K. Chan, Y. Jia, M.J. Lang, J. R. Newman, L. Mets, G.R. Fleming and R. Haselkorn. (1995) Proceedings of the National Academy of Sciences 92(7): 2715. PDF
  • Observation of Ultrafast Energy Transfer from the Accessory Bacteriochlorophylls to the Special Pair in Photosynthetic Reaction Centers. Y. Jia, D.M. Jonas, T. Joo, Y. Nagasawa, M.J. Lang and G.R. Fleming. (1995) Journal of Physical Chemistry 99(17): 6263. PDF
  • Ultrafast Energy Transfer within the Bacterial Photosynthetic Reaction Center. D.M. Jonas, M.J. Lang, Y. Nagasawa, S.E. Bradforth, S.N. Dikshit, R. Jimenez, T. Joo and G.R. Fleming. (1995) Proceedings of the Feldafing III Workshop - Reaction Centers of Photosynthetic Bacteria Structure and Dynamics, Munich, Germany.
  • Recent Abstracts
  • Structural mechanism for force generation by kinesin. Hwang W.M., Lang M.J., Karplus M. (2007) Biophysical Journal, 201A.
  • Mechanics of leukocyte membrane tethering during cell rolling Castro C.E., Boyce M.C., Lang M.J. (2007) Biophysical Journal, 484A.
  • Infecting the single-molecule world: Development of a viral tool for biophysics and mechanics assays. Khalil A.S., Ferrer J.M., Brau R.R., Krauland E.M., Mao J.Y., Noren C.J., Lang M.J., Belcher A.M.. (2007) Biophysical Journal, 520A.
  • Optical trapping of cells and control of multiple particles through silicon. Appleyard D.C., Lang M.J. (2007) Biophysical Journal, 651A.
  • Combined optical tweezers force measurement with simultaneous single molecule fluorescence resonance energy transfer (FRET) detection. Tarsa P.B., Brau R.R., Barch M., Ferrer J.M., Freyzon Y., Matsudaira P., Lang M.J. (2007) Biophysical Journal, 654A.
  • Mechanical role of alpha-actinin in F-actin network organization studied using optical tweezers. Lee, H., Ferrer, J.M., Lang, M.J., Kamm, R.D. (2006) Biomedical Engineering Society Annual Fall Meeting. PDF
  • Optical trapping for biological instrumentation teaching laboratories. Appleyard, D.C., Lee, H., Vandermuelen, K.Y., Lee, P., Lang, M.J. (2006) Biomedical Engineering Society Annual Fall Meeting. PDF
  • Reducing enhanced photobleaching for combined, coincident optical tweezers and single molecule fluorescence. Brau, R.R., Ferrer, J.M., Tarsa, P.B., Lee, P., Appleyard, D.C., Lang, M.J. (2006) Biophysical Journal 90(1). PDF
  • Optical trapping and fluorescence microscope for teaching laboratories. Appleyard, D.C., Lee, H., Vandermeulen, K.Y., Lee, P., Lang, M.J. (2006) Biophysical Journal 90(1). PDF
  • Employing optical tweezers to study the mechanics of filamentous bacteriophage harnessed to nanomaterial scaffolds. Khalil, A.S., Ferrer, J.M., Brau, R.R., Lang, M.J., Belcher, A.M. (2006) Biophysical Journal 90(1). PDF
  • Combining magnetic and optical trapping to quantify position dependent variations in cellular rheology. Su, T-T.J., Brau, R., Jiang, X., Whitesides, G.M., Lang, M.J., So, P.T.C. (2006) Biophysical Journal 90(1). PDF

Last Updated: April 8, 2008