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J. Christopher Love, Ph.D.

Department of Chemical Engineering
Assistant Professor

Room 76-253
(617) 324-2300 (phone)

Biosketch

J. Christopher Love is an assistant professor in chemical engineering at MIT, a member of the Koch Institute for Integrative Cancer Research, an associate member at the Eli and Edythe L. Broad Institute, and an associate faculty at the Ragon Institute of MGH, MIT, and Harvard. Dr. Love received his Ph.D. in 2004 in physical chemistry at Harvard University where he developed a number of unconventional methods to fabricate micro- and nanoscale structures using both soft lithography and self-assembly. He then extended his research into immunology and pathology, first as a research fellow at Harvard Medical School from 2004-2005, and then as an Instructor at the Immune Disease Institute (formerly CBRI) from 2005-2007. Dr. Love was named a Dana Scholar for Human Immunology and W.M. Keck Distinguished Young Scholar in Medical Research in 2009.

Research Summary

Dr. Love's research centers on using simple microsystems to measure and correlate multiple phenotypic and functional characteristics of individual lymphocytes, and from these single-cell data, generate quantitative, system-wide profiles of immune responses. Current areas of research in the lab include i) multiplexed, functional profiling of lymphocytes from HIV+ patients, ii) clonal analysis of autoreactive T cells and B cells in type 1 diabetes and multiple sclerosis, and iii) development of quantitative, cell-based diagnostics for defining immunological signatures.

Selected Publications

  • Story, C.M., Papa, E., Hu, C.A., Ronan, J.L., Herlihy, K., Ploegh, H.L. & Love, J.C. Profiling antibody responses by multiparametric analysis of single B cells. Proc. Natl. Acad. Sci. U. S. A. 105, 17902-17907 (2008).
  • Ogunniyi, A.O., Story, C.M., Papa, E., Guillen, E. & Love, J.C. Generation of monoclonal antibodies using microengraving to screen individual hybridomas. Nature Protocols 4, 767-782 (2009).
  • Han, Q., Bradshaw, E. M., Nilsson, B., Hafler, D. A. & Love, J. C. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab on a Chip 10, 1391-1400 (2010).
  • Love, K. R., Panagiotou, V., Jiang, B., Stadheim, T. A. & Love, J. C. Integrated single-cell analysis shows Pichia pastoris secretes protein stochastically. Biotechnol. Bioeng. 106, 319-325 (2010).
  • Gong, Y., Ogunniyi, A. O. & Love, J. C. Massively parallel detection of gene expression in single cells using subnanoliter wells. Lab on a Chip 10, 2334-2337, doi:10.1039/c004847j (2010).

Last Updated: January 20, 2011