Scott Manalis, Ph.D.
Department of Biological Engineering Division
Associate Professor of Biological Engineering
NEC Career Development Professor of Computers and Communications
Head, Nanoscale Sensing Group
Ph.D. in Applied Physics, 1998
The Manalis laboratory develops quantitative and real-time techniques
for biomolecular detection and single cell analysis. We use conventional
silicon processing techniques to fabricate fluidic devices, and exploit
the unique physical properties associated with micro- and nanoscale
dimensions for developing precision measurement methods.
We have recently developed a technology that enables mass to be measured
in the aqueous environment with a resolution that is a million-fold
better than existing methods. This approach, known as the suspended
microchannel resonator (SMR), places the fluid inside of the resonator
instead of immersing the resonator in the fluid and thereby solves the
long-standing problem of signal degradation from viscous drag. This has
enabled single cells, nanoparticles and biomolecules to be weighed in
solution with femtogram resolution.
We are currently exploring a wide range of biological applications with
the SMR. For example, we are using the SMR's ability to resolve
mammalian cell mass with a precision near ~0.01% to investigate how cell
growth relates to progression through the division cycle, and if the
response of cancer cells to pathway-directed therapeutics can be
classified according to subtle changes in growth.
- J. Lee, W. Shen, K. Payer, T.P. Burg , S.R. Manalis. Toward attogram
mass measurements in solution with suspended nanochannel resonators,
Nano Letters (2010).
- M. Godin, F.F. Delgado, S. Son, W.H. Grover, A.K. Bryan, A. Tzur, P.
Jorgensen, K. Payer, A.D. Grossman, M.W. Kirschner, S.R. Manalis. Using
buoyant mass to measure the growth of single cells, Nature Methods (2010).
- A.K. Bryan, A. Goranov, A. Amon, S.R. Manalis. Measurement of Mass,
Density, and Volume During the Cell Cycle of Yeast, Proceedings of the
National Academy of Sciences (2010).
- T.P. Burg, J.E. Sader, S.R. Manalis. Nonmonotonic Energy Dissipation in
Microfluidic Resonators. Physical Review Letters (2009).
- T.M. Squires, R.J. Messinger, S.R. Manalis. Making it stick: convection,
reaction, and diffusion in surface based biosensors. Nature
Biotechnology, 26 417 (2008).
- T.P. Burg, M.Godin, S.M. Knudsen, W. Shen, G. Carlson, J.S. Foster, K.
Babcock, and S.R. Manalis. Weighing of Biomolecules, Single Cells, and
Single Nanoparticles in Fluid.Nature, 446 1066 (2007).
Last Updated: January 31, 2011