The CSBi Microsystems Core is creating micro-laboratories through integration of sensors, actuators, and controls with on-chip fluidic channels, that can be used to address fundamental problems in systems biology. The advantage of these micro-laboratories is that they enable massively parallel sample preparation, manipulation and high throughput measurement.
The Core supports the development of functional micro- and nano-structured materials and devices for in vivo quantitative biological and chemical measurement at low sample volumes. These devices are fabricated in the Microsystems Technology Laboratory (MTL) in the School of Engineering and the MIT Media Laboratory. In supporting these activities, a major goal of the Core is to expand biological applications of MTL.
The CSBi Microsystems Core combines capabilities in the Microsystems Technology Laboratory (MTL) in MIT’s School of Engineering and MIT's Media Lab. The Core supports the fabrication of micro-scale, high-throughput, real time and quantitative measurement technologies for biological applications.
MTL and the CSBi Microsystems Core provide hands-on training and guidance for design of experiments. Please see the MTL website for more details.
Microsystems Technology Laboratory, MIT Bldg 39
- Scientists can use existing microfabrication technology to create nano to microscale devices from silicon, glass or polymers and functionalize the surfaces of these devices with a particular chemical or biological activity.
- Microfluidic techniques, externally driven flows or electrokinetic flows are used to manipulate biological samples through specialized three-dimensional structures. These structures can have chemical, mechanical or electrical properties that allow precise measurement of many different parameters including facilitating cell growth, delivering various stimili, cell sorting and lysis, and chromatographic separation and detection of biological phenomena.
Heidelberg Instruments Direct Laser Writer, MIT Bldg. 39
The Heidelberg Laser Writer is an efficient, high-resolution direct pattern generator for making 2D and 3D microstructures on various substrates such as glass or silicon wafers. The alignment system provides for accurate and reproducible production of nanobiotechnonlogy and microfabricated devices. Researchers can work with CSBi staff to create designs that are then converted for laser writing and subsequent steps in the microfabrication process are performed in the clean room of the MTL or the Nanoscale Sensing Group in the MIT Media Lab.
Klavs Jensen Chemical Engineering
Scott Manalis Biological Engineering, Media Arts and Sciences
Martin Schmidt Electrical Engineering and Computer Science,
Microsystems Technology Laboratory (MTL)