The Biophysical Instrumentation Facility houses instrumentation for aiding in the elucidation of macromolecular structure. The facility was established by Dr. Barbara Imperiali and is located in the Dreyfus Chemistry Building (18-511). It is largely used by researchers in Chemistry, Biology and Biological Engineering but is available to anyone on campus and beyond. It is staffed 40 hours a week by Debby Pheasant who is available to train new users and provide advice to anyone considering potential applications of the equipment in the facility. For inquiries, contact Debby Pheasant at pheasant@mit.edu.
| Instruments | Applications | Location |
| Beckman XL-I Analytical Ultracentrifuge | calculating the molecular mass, stoichiometry, conformation and shape of proteins in solution | 18-511 |
| Aviv Model 202 Circular Dichroism Spectrometer | information on secondary structure: alpha-helix, beta-sheet or random coil | 18-511 |
| MicroCal Isothermal Titration Calorimeter | calculate stoichiometry, binding constant, enthalpy and entropy | 18-511 |
| MicroCal Differential Scanning Calorimeter | information about subunit composition, folding and stability | 18-511 |
| DynaPro Titan Light Scattering Instrument | molecular weights of the different species in a sample and their size distribution | 18-511 |
| Perkin Elmer HTS 7000 Bio Assay Reader | reads fluorescence from the top or bottom of microwells in a plate | 18-511 |
